Give Back Health Clinic Collection MagRegulate® combines a highly bioavailable form of magnesium with clinically trialled dosages of taurine and L-glycine. It modulates mood, supports nervous system response and optimises metabolic, mitochondrial and cardiovascular health.It is a listed medicine (AUST L 430698) on the Australian Register of Therapeutic Goods (ARTG) and comes in powder form.

• Clincally dosed inline with the literature for maximum therapeutic impact.
• Regulates mood, nervous system excitation and neurotransmitter dysfunction.
• Provides potent synergistic effects to regulate mood, neuroinflammation, oxidation, neurotransmitter dysfunction, neuroexcitation, cellular homeostasis and metabolic function.
• Targeted fast acting and long lasting actions on the central nervous system.
• Reduces the occurrence and severity of anxiety and depression.
• Promotes energy, longevity and optimal metabolic function.
• Two pack sizes: 255g (30 day supply), 510g (60 day supply).

• Magnesium (Mg2+) is a vital micronutrient and co-factor or activator of a huge number of reactions in the body. Low magnesium status has been shown to correlate with poor mental health.
• Magnesium functions synergistically with glycine, supporting nervous system health and protecting neurons from inflammation.
• Magnesium modulates neuroinflammation through interactions with NMDA receptors.
• Magnesium improves symptoms of mild to moderate depression.
• Magnesium modulates neuroexcitation and optimises neurotransmitter function.
• Taurine is an amino acid and inhibitory neurotransmitter found in nerve and muscle tissue. It acts as an agonist at GABA and glycine receptors, modulates calcium influx, modulates glutamatergic signalling and prevents excitotoxicity and oxidative stress. It helps protect the nervous system, reduce neuroinflammation, reduce nervous system excitation and regulate metabolic function.
• Glycine is a conditionally essential amino acid which acts rapidly in the central nervous system to inhibit excitation. As there is no regulation over its uptake, including glycine in formulations is beneficial, particularly when the brain is under excitatory overload (e.g. conditions such as depression, acute stress, drug use and extreme insomnia).
• Glycine crosses the blood brain barrier by passive diffusion and, unlike taurine, uptake is not limited by receptor site availability. L-glycine has no inhibition of uptake, so what you consume can be quickly absorbed into the body and in turn quickly have a calming effect on the central nervous system (CNS).
• Glycine provides effective antiinflammatory actions in the CNS.
• Glycine supports sleep onset, duration, quality and architecture.
• Improves and prevents anxiety, stress and depression.
• Targets mental health synergistically through regulation of inflammation, oxidation, neurotransmitter function and cellular homeostasis.
• Reduces nervous system excitation and protects and calms the nervous system.

Give Back Health Clinic Collection MagRegulate® contains ingredients with research to support the regulation of neuroinflammation, oxidation, neurotransmitter dysfunction, mood, neuroexcitation, cellular homeostasis, metabolic function and sleep. Below are spotlights on mood regulation and metabolic regulation. See factsheet for specific scientific findings and a full list of references.

Mood regulation

• Magnesium effective for relieving symptoms of mild to moderate depression.
• Magnesium improved depression status in patients with magnesium deficiency.
• Taurine reduced inflammation and impairment to blood brain barrier in institutionalised older females.
• Systematic review on magnesium for mood regulation reports five clinical trials with positive results in depression.
• Magnesium shown to reduce stress in healthy participants.
• Magnesium supplementation improved efficacy of fluoxetine in patients with depression.
• High dose glycine effective adjuvant for modulating glutamatergic neurotransmission.
• Seven studies demonstrate correlation between reduced magnesium and symptoms of depression.

Metabolic regulation

• Meta-analysis of magnesium on glycemic indices and metabolic status in gestational diabetes found a significant reduction in markers of glycemic control, fasting plasma glucose and insulin levels.
• Obese participants on a weight-loss diet plus taurine 3 g taurine/day had significant improvements in TC, LDL-C, leptin, and adiponectin than the diet plus placebo group.
• Systematic review of magnesium intake found a significantly inverse associations with T2D and the association was dose-dependent.
• Taurine supplementation reverses early endothelial dysfunction in young men with T1DM.
• Supplemental taurine reduces glycemic indices, such as HbA1c, fasting blood sugar, HOMA-IR in diabetic patients.
• Magnesium supplementation associated with lower waist circumference in obese participants.
• Significant improvements in glycemic status, lipid profile and blood pressure observed with taurine supplementation (FBS, glycated haemoglobin, HOMA-IR, TC LDL-C and SBP and DBP) as well as reduced advanced glycation end products.
• Taurine improved the glycemic indexes (FBS,HOMA-IR) and lipid profiles (TC, LDL-C) in participants with T2DM.

Give Back Health Clinic Collection MagRegulate® is helpful for people:

• Struggling with mood and mental wellbeing.
• Wanting to reduce the occurrence of mental health decline.
• With stress, anxiety, depression and related mental health challenges.
• With overactive nervous systems (sympathetic dominance).
• In recovery from substance use disorder.
• With metabolic dysfunction, pre-diabetes and blood glucose regulation challenges.
• Wanting to optimise cardiovascular and blood glucose parameters.
• Wanting to improve health and optimise overall wellness parameters.
• Wanting to improve sleep quality, duration and waking feeling refreshed.
• MagRegulate® is also suitable for children, adults and older adults.

• To improve mood and mental wellbeing.
• To protect the nervous system and reduce the occurrence of poor mental health (e.g. anxiety and depression).
• To help downregulate an overactive nervous system.
• To inhibit nervous system excitation (regulate excitable neurons).
• To reduce stress, anxiety and overwhelm.
• To help calm the nervous system and reduce neuroinflammation.
• To help protect the nervous system and regulate an optimal nervous system response.
• To help regulate neurotransmitter dysfunction.
• To improve metabolic function and optimise metabolic health.
• To improve cardiovascular function and optimise cardiovascular health.
• To improve mitochondrial health.
• To improve sleep onset, sleep duration and overall sleep architecture.

When selecting a magnesium, L-glycine or taurine product, key factors include clinical research on the raw materials, clinical dosing, purity, excipient profile and manufacturing standards. Unlike herbal ingredients, which are complex and vary significantly across the many different grades available, single nutrients are far simpler to assess. Source and quality are still essential, but they are much easier to control and verify. If a material is authenticated and genuinely pure, the body can be expected to respond the same way regardless of supplier or brand name. Where this cannot be confirmed, the supplier and manufacturing process become critical.
The key questions to ask are: Is it pure? Has every batch been independently tested to confirm this? Is it free from impurities? Is it the correct isomer, where relevant? Is it stable over time and in combination with other ingredients?

Our magnesium, L-glycine and taurine meet every one of these criteria. They are authenticated, independently tested on every batch, free from impurities, the correct isomer where relevant, and stable, so you can be confident you are receiving the full clinical dose stated on the label.

This practitioner-only formulation stands apart through its clinical integrity and evidence-aligned design. Key points of difference include:

• Therapeutic dosing based on the latest research.
MagRegulate® contains the clinically trialled dosages of glycine (3g) and taurine (3g), and the clinically meaningful dose of magnesium (350mg).
• Bioavailable ingredient forms to maximise absorption and clinical outcomes. 
MagRegulate® contains a highly absorbable form of magnesium as magnesium citrate.
• Manufactured in a TGA-licensed GMP facility to ensure consistent quality.

• Comprehensive third-party testing for potency, purity and contaminants.

• Minimal excipients, no unnecessary fillers or additives. MagRegulate® is an extremely clean formula with only some extra glycine added for manufacturing. There is a negligible quantity of colloidal anhydrous silica, which is a requirement of the manufacturing process.

This product is designed to offer clinicians peace of mind and patients better outcomes, supporting targeted use in a range of clinical applications.

Suitable for use alongside most medications.

• Levodopa/carbidopa: Magnesium can reduce the bioavailability of levodopa/carbidopa. These ingredients should not be taken together.

At Give Back Health, we follow a conservative risk/benefit approach and recommend healthcare practitioners assess use on a case-by-case basis, depending on individual patient needs, context and response to treatment.

• Magnesium: Likely safe in pregnancy and lactation when used appropriately. The Natural Medicines Database rates oral magnesium intake up to 350 mg/day as safe within this population. MagRelax® delivers 350 mg per 5.3 g scoop.
• Glycine: While Glycine is not specifically contraindicated in pregnancy and lactation, there is insufficient reliable evidence so we recommend a risk/benefit approach to use. 
• Taurine: While Taurine is not specifically contraindicated in pregnancy and lactation, there is insufficient reliable evidence so we recommend a risk/benefit approach to use. 

We recommend MagRegulate during preconception to help support the nervous system, manage stress, and assist in overall body regulation. However, we do not advise using it during IVF treatment, as the amino acids glycine and taurine, while important for many normal processes, have limited safety data when taken as isolated nutrients during pregnancy.

In this phase, many fertility clinics instead use our NR, NAC, and zinc picolinate (in both males and females) to support a range of key fertility parameters for both partners.

• Mix 1 level scoop (8.5 g) into water and consume immediately. Suitable for use during the day or take 30 minutes before bed to enhance refreshing sleep.
• The common dosage range for magnesium is 350 – 700 mg/day
• The common dosage range for taurine is 3 – 6 g/day
• The common dosage range for glycine is 3 – 9 g/day

Glycine has a very quick onset. Individuals should experience a calming effect within 30 minutes (for nervous system excitation and sleep benefits). For other benefits, results are generally seen within 2-4 weeks, with further improvement by 8-12 weeks.

Give Back Health Clinic Collection MagRegulate® is a clean formula free from flavours, sweeteners or commonly used excipients. It is an ultra-low excipient formulation with minimal low-to-no allergen excipients (e.g. glycine, colloidal anhydrous silica). Check the ingredient and excipients list for a complete breakdown. See the Free Froms & Allergy Info details in the main product description above.

Give Back Health Clinic Collection MagRegulate® is manufactured and tested in TGA-registered GMP facilities here in Australia, ensuring high standards of quality, safety and efficacy. Every product, every batch, with no exceptions.

Give Back Health Clinic Collection MagRegulate® is most commonly used alongside our Saffron + Zinc, RejuveGen®, Curcuma Phospholipids, NAC and Sleepatonin® for additional support, depending on clinical goals.

Magnesium citrate is a highly bioavailable and well-researched form. Glycine is included in MagRegulate® at a clinically validated therapeutic dose. To get the same glycine dose using magnesium glycinate, you'd need a significantly higher magnesium intake, which could cause gastrointestinal side effects like diarrhoea. MagRegulate® allows you to get the full benefits of both ingredients without overloading the system.

Give Back Health Clinic Collection MagRegulate® contains only three ingredients: magnesium citrate, taurine and glycine. Glycine is naturally sweet, which gives MagRegulate® its mild taste. No sweeteners or flavours have been added.

Yes, but with a small caveat. While the magnesium component remains stable in warm drinks, glycine can degrade when exposed to high heat. If you're adding it to a warm beverage, avoid boiling water and drink it soon after mixing for best effect. Our recommendation is add to room temperature or cold water and consume immediately.

Give Back Health Clinic Collection MagRegulate® is suitable for both day and night use. Choose the timing that best supports your needs (or go both).

How do I choose between MagRegulate® and MagRelax®?
MagRegulate® is sister product to MagRelax®. Use MagRelax® to relax and nurture the central nervous system (CNS) when under excitation. Use MagRegulate® to regulate a range of processes and systems once the CNS is relaxed and more receptive to taurine.

• Taurine has many roles in the body, but one essential and often over looked one it its role as a major antioxidant in our brains.
• When the brain is under high antioxidant stress, taurine helps reduce oxidation through multiple mechanisms (including reducing glutamate and inflammation) to protect our brains from neuronal damage. Here, Taurine is pushed out of the brain into the extracellular space so it can work its magic across multiple pathways.
• What this results in though is an increased concentration of taurine in the extracellular space and a resulting inhibition of absorption from supplementation or dietary intake. The body thinks it has a sufficient quantity, when actually it has just moved from where it was to protect the brain from neuronal damage.
• In these instances of high oxidative stress in the brain (e.g. alcoholism, drug use, serious mental health presentations) we will get better therapeutic results for our clients supplementing with Glycine (MagRelax®) instead of taurine (MagRegulate®) (for antioxidant, CNS inhibitory and anti inflammatory effects) to allow the body and CNS to normalise, and then once it is normalised, we can supplement again with Taurine (MagRegulate®) (which will be absorbed as we are no longer impacted by the negative feedback loop) so taurine can have its profound therapeutic effects.