Give Back Health Clinic Collection GABA is a practitioner-only nutritional supplement that provides 100% pure medicine-grade GABA. It comes in powder form and is designed for extemporaneous compounding and prescribing under practitioner supervision. Gamma-Aminobutyric Acid (GABA) is an inhibitory neurotransmitter in the central nervous system (CNS) and is critical in balancing neuronal excitation with inhibition. GABA shows promise for its calming actions and sleep promoting properties. It is particularly useful for promoting concentration in stressful situations.

• Reduces stress and anxiety.
• Improves concentration, particularly when stress is present.
• Provides a calming effect, relaxation response and sleep promoting properties.
• Promotes relaxed alert state.

GABA is the primary inhibitory neurotransmitter in the CNS. It helps balance neuronal excitation and inhibition, supports relaxation, and may influence peripheral pathways through the gut-brain axis. GABA is a neurotransmitter produced in the body that plays a role in supporting a calm, relaxed state. It helps balance the nervous system and may support mental clarity in times of stress. GABA is an inhibitory neurotransmitter in the central nervous system (CNS) and is critical in balancing neuronal excitation with inhibition. GABA is an inhibitory neurotransmitter that binds to GABA-A receptors in the brain, promoting hyperpolarisation of neurons and reducing excitability in the CNS.

• Reduces neuronal activity which is associated with a calming effect.
• Promotes alpha waves and a significantly high alpha: beta wave ratio compared to placebo.
• Both acute and chronic stress both impact normal GABAergic transmissions particularly in some regions of the brain.
• Animal studies indicate that stress impacts the GABAergic interneuronal network and reduction in GABA activity may be related to anxiety and sleep disturbance.
• Provides CNS modulation.

See factsheet for specific scientific findings and a full list of references.

• GABA is an inhibitory neurotransmitter in the central nervous system (CNS) and is critical in balancing neuronal excitation with inhibition.
• GABA is also involved in the enteric nervous system.
• Oral GABA may cross the blood brain barrier via the GABA transporter system, but this is yet to established, or it may act via the peripheral nervous system and the gut-brain axis.
• Studies suggest GABA induces relaxation, in part via modulating the sympathetic nervous system.
• A disruption in the equilibrium of excitatory glutamatergic and inhibitory GABAergic pathways has been hypothesized to have a role in the pathogenesis of Autism Spectrum Disorder (ASD).
• The excitatory-inhibitory imbalance theory of autism suggests a GABAergic deficit which is supported by post-mortem and genetic studies providing support for this theory of ASD.
• GABA is an effective option for stress and anxiety.
• GABA is an effective option for improving sleep quality.
• GABA is an effective option for concentration and focus, particularly when stress is involved.

• People experiencing anxiety, low mood and high levels of stress which may be affecting their concentration and sleep, among other things.
• People with Autism Spectrum Disorder (ASD) currently undergoing other treatment.
• Adults and children.

When selecting a GABA product, key factors include ingredient form, clinical dosing, purity, excipient profile and manufacturing standards. This product has been specifically developed for practitioner use and compounding, with:


• High-quality, verified raw materials with full traceability.

• Manufacturing in a TGA-licensed GMP facility in Australia.

• Rigorous third-party testing to ensure potency, purity and absence of contaminants.

• 100% pure GABA powder with no excipients suitable for sensitive patients and custom blends.
  

This product prioritises efficacy, quality assurance and suitability for tailored prescribing, giving you clinical confidence and patient clarity. Unlike most therapeutic and extemporaneous compounding powders in the marketplace, all our products – including Give Back Health Clinic Collection GABA – are manufactured and tested in TGA-registered GMP facilities here in Australia, ensuring high standards of quality, safety and efficacy. Every product, every batch, with no exceptions. This means the included ingredients are what they claim to be and the products are therefore more likely to have an actual therapeutic impact. This process also prevents counterfeit and adulterated materials from entering the market. While it adds significantly to our costs, we believe this level of integrity should be the industry standard. Please note that we absorb the extra expense ourselves; it is not passed on to you.

In short, yes. Powders for extemporaneous compounding sit in a unique therapeutic category with its own set of rules. When you choose to use a compounding powder, the expectation is that you will be combining this with other therapeutic nutrients and ingredients to create a personalised medicine. Single ingredient prescribing is, however, possible with extemporaneous compounding ingredients with best practice to ensure that the amount of product in the jar represents the full course for the patient. The quantity of any ingredient you use will be calculated in relation to the prescription length and daily required dose, which is completely specific to an individual patient’s presentation and needs.

While GABA is generally well tolerated, it may theoretically enhance the effects of antihypertensives, increasing the risk of hypotension. Some clinical research shows that GABA can decrease blood pressure in patients with hypertension. Recommendations:

• Separate GABA by at least 2 hours from antihypertensives.
• Advise patients to monitor for dizziness on standing, or noticeable drops in BP.
• Report any concerning changes for further clinical review.

Additionally, these combinations should be used with caution:

• Lercanidipine (antihypertensive): Monitor for hypotension.

While GABA is not specifically contraindicated in pregnancy and lactation, there is insufficient reliable evidence so we recommend avoid use.

• We typically recommend taking with water.
• The common dosage for GABA: 200 - 800 mg.
• Without knowing your patient’s presentation and requirements, we cannot provide guidelines around appropriate daily dosing and suggest you refer to the literature and common dosage ranges when creating your prescription. Our team of naturopaths are also available for further guidance.

Results are generally seen within an hour for calming effects. For other effects, results are generally seen within 2-4 weeks, with further improvement by 8-12 weeks.

This product contains no excipients. It is 100% pure GABA.

Unlike most therapeutic and extemporaneous compounding powders in the marketplace, all our products – including Give Back Health Clinic Collection GABA – are manufactured and tested in TGA-registered GMP facilities here in Australia, ensuring high standards of quality, safety and efficacy. Every product, every batch, with no exceptions. This means the included ingredients are what they claim to be and the products are therefore more likely to have an actual therapeutic impact. This process also prevents counterfeit and adulterated materials from entering the market. While it adds significantly to our costs, we believe this level of integrity should be the industry standard. Please note that we absorb the extra expense ourselves; it is not passed on to you.

GABA is most commonly used alongside our L-Theanine, NAC, Nicotinamide Riboside (NR), Saffron + Zinc, Mood-D and MagRegulate® for additional support, depending on clinical goals.

GABA may be relevant in supporting CNS regulation, but prescribing should be made in the context of a full clinical history.