NR 300 features branded UthGene™ NR, from the same trusted source behind our Uthever® NMN. Every batch is 100% pure, verified and authenticated for NR content, providing a reliable option to boost NAD+ levels in the body, help counter the natural age-related decline and support energy production, mitochondrial function and healthy ageing. This is the same trusted NR Give Back Health introduced to the Australian market, now in a capsule. It is a listed medicine (AUST L 527592) on the Australian Register of Therapeutic Goods (ARTG).

• Features UthGene™, 100% pure pharmaceutical grade NR from EffePharm who are an established leader in the NAD+ precursor space and the same trusted source behind our Uthever® NMN.
• Boost NAD+ levels in the body and helps counter the natural age-related decline.
• Supports energy production, energy levels and mitochondrial function.
• Provide antioxidant support.
• Support healthy ageing and longevity.
• Suitable for long-term use.

• Oral NR significantly increases NAD+ in a dose-dependent manner.
• NAD+ is an essential redox coenzyme central to energy production, metabolic homeostasis and mitochondrial energy metabolism.
• NAD+ is the required substrate for sirtuin activity, with the beneficial effects from NAD+ dependent sirtuins only achieved if NAD+ levels are optimal.

See factsheet for specific scientific findings and a full list of references.

NR increases NAD+ levels to prevent, delay, or improve NAD+ dependent ageing mechanisms influencing the seven diseases of aging. NR is one of the most researched and well understood NAD+ precursors (along with NMN), with multiple clinical trials demonstrating its action across multiple body systems.

NAD+ is an essential redox coenzyme central to energy production, metabolic homeostasis and mitochondrial energy metabolism, and the required substrate for sirtuin activity, where benefits depend on optimal NAD+.
As NAD+ naturally declines with age, driven by factors including oxidative stress, inflammation, metabolic stress and DNA damage, maintaining optimal levels supports the hundreds of enzymatic reactions and pathways that depend on it, from energy metabolism and DNA repair to mitochondrial function, biogenesis and overall homeostasis.

Healthy Ageing

• NR may provide protection against diseases of ageing and diseases characterised by inflammation through its ability to effectively raise NAD+ levels.
• NAD+ has a fundamental role in the central metabolic pathway and the formation of ATP.
• Cognitive decline is associated with oxidative stress and DNA damage.
• NAD depletion is implicated in the pathogenesis of Inflammatory Bowel Disease, cardiovascular disease and neuromuscular diseases in animal models.
• NR shown to decrease aortic stiffness and systolic blood pressure (SBP) when compared to placebo.
• NR increased mitochondrial respiration and reduced ROS production for enhanced cardiac function.
• NR shown to increase cerebral NAD levels and animal studies indicate a potential role for NR in the prevention of cognitive decline.
• Orally administered NR shown to slow axon degeneration and protect against loss of dopamine neurons in Parkinson’s Disease via modulating peripheral myelination.
• NR is shown to increase mitochondrial metabolism and protect against mitochondrial DNA damage in the kidneys.
• NR demonstrates potential to stabilise bone density by promoting osteoblast maturation and inhibiting overactivation of osteoclasts.
• NR preserves skin elasticity, epidermal thickness and enhances wound healing by promoting collagen production and upgregulating cellular turnover and regenerative capacity.
• In animal models, NR slowed extracellular matrix degradation and reduced hyperpigmentation.
• NR stimulates mitochondrial morphology and mitophagy, preserving ocular longevity, neuromotor activity and eye coordination.
  

Metabolism and Energy Optimisation

• Obesity is associated with declining levels of NAD+.
• Metabolic disorders (including obesity and T2DM) are associated with a reduced expression of the NAD+ dependent enzymes SIRT1 and 2 due to insufficient quantities of NAD+.
• Upregulation of NAD+ synthesis can influence metabolic processes regulated by sirtuins.
• Supplementation of NR in healthy overweight/obese participants resulted in increased metabolism of lipids and reduced fat mass.
• NR improves mitochondrial function and reverses muscular atrophy to reduce fatigue and increase endurance, strength and overall exercise performance.
• Animal studies demonstrate NR’s role in improving cellular resilience to physiological stress.
• NR supplementation improves resistance to fatigue in older individuals.
• NR upregulates insulin production and sensitivity as well as enhances fatty acid oxidation and citric acid cycle activity to improve glucose and cholesterol metabolism.
  

Antioxidant support

• The reduced form of NAD+, NADPH, is an essential coenzyme for several major antioxidants including glutathione.
• A study of healthy older men found supplementation of NR reduced the expression of circulating inflammatory cytokines and reduced oxidative species (ROS) particularly in the lungs, liver and blood vessels.

• People wanting to increase NAD+ for a range of positive health benefits.
• People with chronic health conditions, particularly those linked to NAD+ decline.
• People chasing more energy and improvements to mitochondrial health.
• People wanting to improve overall wellness and healthy ageing parameters.
• Suitable for children 12+ years, adults and older adults.

• To increase NAD+ for overall general wellbeing.
• In chronic conditions mediated by high oxidative stress, inflammation or NAD+ dependent pathways.
• To support mitochondrial function, energy metabolism and energy production.
• To improve NAD+ levels (which naturally decline with age) for a diverse range of health benefits.

There have been multiple preclinical and clinical trials conducted demonstrating NR’s role in benefiting:

• Age related physiological changes
• Neuroprotective and cognitive function including in Alzheimer’s disease
• Axon degeneration in Parkinson’s disease
• Acute kidney disease
• Obesity, insulin resistance and metabolic dysfunction including diabetes
• Cardiometabolic and cardiovascular conditions
• Musculoskeletal conditions (i.e. Duchenne Muscular Dystrophy [DMD], and sarcopenia)
• Fatigue, including mitochondrial myopathy and Inclusion Body Myositis (IBM)
• Eye coordination and dysfunction (including Ataxia-Telangiectasia)
• COPD
• NAFLD and ALD

See factsheet for more information on NAD+’s benefit on multiple body systems.

When selecting an NAD+ precursor product, key factors include clinical research on the raw material, clinical dosing, purity, excipient profile and manufacturing standards. NR is a reactive molecule, often becoming unstable during manufacturing, transport and storage. When tested, many NAD+ precursor products (including NMN and NR) contained only minimal amounts of the active or, in some cases, a completely different ingredient overall.

• NR 300 Features branded UthGene™ NR, from the same trusted source behind our Uthever® NMN.
• It is the same NR Give Back Health introduced to the Australian market.
• Every batch is 100% pure, verified and authenticated for NR content.
• Manufactured in an Australian TGA-licensed GMP facility to ensure consistent quality.

• Comprehensive third-party testing for potency, purity and contaminants.
• Minimal excipients, no unnecessary fillers or additives. NR 300 is a clean formula with only the necessary excipients added as a requirement of the manufacturing process. Even our capsules are the cleanest available, made from hypromellose derived from sustainably sourced pine trees.
  

This product is designed to offer clinicians peace of mind and patients better outcomes, supporting targeted use in a range of clinical applications.

No major interactions. NR is well tolerated in clinical trials.

• Not recommended for use during pregnancy or lactation.
• Not to be taken by children under 12 years of age.
• Contains sugar as ribose.
• Vitamin and mineral supplements should not replace a balanced diet.

At Give Back Health, we follow a conservative risk/benefit approach and recommend healthcare practitioners assess use on a case-by-case basis, depending on individual patient needs, context and response to treatment.

NR has been reported by the expert scientific ESFA panel as being safe for use during pregnancy and lactation up to 230 mg. As the dose contained in NR 300 is higher than the reportedly safe amount for use in pregnancy and lactation, we recommend to avoid use.

Take 1 capsule daily.

Listed medicines are restricted to 300 mg of NR as the maximum daily dose (1 capsule of NR 300).

The common range for NR as per the clinical trials is between 300 mg – 1,000 mg per day. It is generally well tolerated at these levels, and benefits are shown to be dose dependent (the higher the dose, the better the results).

Results are generally seen within 1-2 weeks, with further improvement by 6-12 weeks.

Give Back Health Clinic Collection NR 300 is a clean formula free from many commonly used excipients, making it a suitable option for many. It is a low excipient formulation with minimal low-to-no allergen excipients. See the Free Froms & Allergy Info details in the main product description above.

• Excipients include: Leucine, microcrystalline cellulose, calcium hydrogen phosphate dihydrate, colloidal anhydrous silica, hypromellose.
• Incidental minor excipients: None.

Give Back Health Clinic Collection NR 300 is manufactured and tested in TGA-registered GMP facilities here in Australia, ensuring high standards of quality, safety and efficacy. Every product, every batch, with no exceptions. This means the included ingredients are what they claim to be and the products are therefore more likely to have an actual therapeutic impact. This process also prevents counterfeit and adulterated materials from entering the market. While it adds significantly to our costs, we believe this level of integrity should be the industry standard. Please note that we absorb the extra expense ourselves; it is not passed on to you.

We use UthGene™ NR by EffePharm, an established leader in the NAD+ precursor space and the same trusted source behind our Uthever® NMN. It is the same NR Give Back Health introduced to the Australian market. The NR we use is the chloride form (nicotinamide riboside chloride) as this is the only one approved by the TGA for use in Australia. Additionally, it is vegan and 100% pure medicine-grade NR. It is a highly targeted, premium quality and clinically trialled active ingredient which we believe should be the standard in our industry.

We use gold-standard Capsugel® Vcaps® plus capsules from Lonza, widely considered the cleanest on the market. Unlike many capsules that contain gelatine or unnecessary additives like sodium lauryl sulphate, ours are made from just one ingredient: plant-based hydroxypropylmethylcellulose (HPMC) (AKA hypromellose), derived from sustainably sourced pine trees. That’s it. These capsules are vegan, non-GMO Project Verified, Kosher and Halal certified, and Vegetarian Society approved.

Give Back Health Clinic Collection NR 300 is most commonly used alongside our NMN, MagRegulate®, MagSleep®, Lion's Mane Premium Organic, RejuveGen® and Multi VMN for additional support, depending on clinical goals.

The Maximum recommended dose that can be recommended for listed medicines for NR is 300 mg (1 capsule of NR 300). The common range for NR as per the clinical trials is between 300 mg – 1,000 mg per day. It is generally well tolerated at these levels, and benefits are shown to be dose dependent (the higher the dose, the better the results).

NMN and NR are both NAD+ precursors with different metabolic processes. Where NMN needs to be converted to NR before entering the cell, NR can cross directly via equilibrative nucleoside transporters (ENTs), where it is then converted to NMN via nicotinamide riboside kinase (NRK) enzymes 1 & 2 inside the cell, where it can then be used to produce NAD+.

Both have been shown to increase NAD+ levels and benefit various body systems.

See NMN VS NR Research Highlights for a complete overview of both these NAD+ precursors.

Yes. 300 mg per day of Nicotinamide Riboside (NR) is a safe dose for long term use.

NR 300 can be prescribed for children over 12 years of age where deemed appropriate by a healthcare practitioner.

Nicotinamide adenine dinucleotide (NAD+) is an essential molecule that plays a critical role in almost every metabolic process in the body. Through its roles as a cofactor, electron donor and signalling molecule, NAD+ is essential for many biological processes. These include ATP synthesis, DNA repair, secondary messenger signalling, epigenetic regulation of gene expression and cell survival. NAD+ naturally declines with age. The gradual decline of NAD+ concentrations takes place across multiple human organs and tissues, including skin, blood, liver, muscles and brain. Reduced concentration of NAD+ results in suboptimal functioning of the NAD+ dependent pathways. This in turn results in an increase in issues relating to metabolic function, inflammation, senescence and degeneration of the nervous system. When NAD+ dependent mechanisms are compromised, diseases of ageing are then more likely to occur. By increasing NAD+ and therefore increasing the activity of the NAD-dependent processes, we can help prevent, delay or improve the NAD+ mechanisms of ageing. In doing so, we can prevent, delay or improve the seven diseases of ageing.