Give Back Health Clinic Collection Lion’s Mane Premium Organic is a practitioner-only nutritional supplement that provides authenticated, organic, 100% pure medicine grade lion's mane. Sourced from the USA, it is the most premium lion’s mane available with industry first of 57% beta glucan content. It comes in powder form and is designed for extemporaneous compounding and prescribing under practitioner supervision. Lion’s mane (Hericium erinaceus) is renowned for its beneficial effects as a neuroprotector, with huge potential in protecting against cognitive, visual and auditory decline. Through its synergistic actions in the microbiome and inflammatory modulation, lion’s mane also shows a high degree of promise in supporting the immune system and metabolic balance. It is the only lion's mane suitable for practitioner prescribing.

• Popular medicinal mushroom that provides neuroprotective properties on the nervous system and brain.
• Stimulates nerve growth factor synthesis, neurogenesis, peripheral nerve regeneration and muscle regeneration.
• Helps protect against cognitive decline and neurodegeneration.
• Improves GIT health and reduces GIT inflammation.
• Improves microbiome diversity.
• Supports immune system health.
• Regulates blood sugar, blood lipids and metabolic balance.
• Promotes healthy ageing, longevity and vitality.
• Provides the most effective, practitioner-grade lion's mane suppment, with 57% beta glucans.

• Activates synthesis of nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF), which are vital to neurogenesis, long term cognitive health and prevention of AD.
• Constituents’ including adenosine and herierin III have neuroprotective actions.
• In vitro studies have shown antioxidant and neuroprotective actions in cells exposed to both environmental and endogenous nervous system stressors.
• Inhibition of proinflammatory cytokines TNFα, IL-1β and IL-6.
• Modulates the expression of important cytoprotective proteins including heme oxygenase-1 (HO-1), heat shock protein 70 (Hsp70), and thioredoxin (TRX), all crucial to cellular stress response and diminished in the ageing brain.
• In vitro and in vivo studies support the potential effects in acute nerve damage and peripheral nerve regeneration.
• The constituents hericenones and erinacines are found to increase myelination (found in the mycellium and fruiting body).
• Synergistic effect from multiple constituents support microbiome diversity, anti-inflammatory activity and immune modulation.
  - Decreases NFΚB and TNFα expression in inflamed tissue.
  - Activates T cells for immune response.
  - Modulates enzymes required for immune function and antibacterial activity.
  - Rebalances the microbiome from proinflammatory to anti-inflammatory species.
  - Inhibits proinflammatory cytokines.
  - Regulates gut microbiota and related immune system function.
• Metabolic syndrome, T2DM and CVD are all associated with dysbiosis.
• Evidence from animal research shows that a polysaccharide constituent can lower total cholesterol by ~33%, LDL cholesterol ~ 45%, and triglycerides by ~34%, as well as increase HDL cholesterol by 31%.
• The hypolipidemic effect of Hericium erinaceus polysaccharide was attributed to its ability to inhibit HGM-CoA reductase activity, and possibly its ability to reduce cholesterol absorption.
• Suppresses lipopolysaccharide induced inflammation and protects against hydrogen peroxide oxidative stress.

See factsheet for specific scientific findings and a full list of references.

• Two small placebo controlled clinical trials, reported improvements in cognitive function after 12 and 16 weeks compared to placebo.
• A pilot study showed potential benefit from lion’s mane in early stage Alzheimer’s Disease.
• Traditionally indicated for declining cognitive function and memory loss.
• Human clinical studies demonstrated that lion’s mane:
  - Increases microbiome species diversity.
  - Upregulates SCFA producing species.
  - Reduces potential pathogenic species in the GIT.
  - Reduces inflammation and pain in the GIT.
• Microbiome diversity is associated with improved immune function.
• Constituents including erinacerin inhibit alpha-glucosidase and therefore slow the release of glucose from dietary CHOs, reducing postprandial glucose and insulin levels.
• Traditionally used in diabetes mellites and cardiovascular conditions.

Give Back Health Clinic Collection Lion's Mane is suitable for people experiencing:

• Chronic conditions associated with neuroinflammation and neurodegeneration.
• Conditions involving cognitive impairment.
• Prevention of age-related neurological decline; visual, auditory and cognitive decline.
• Potential adjunct in conditions involving demyelination (e.g. multiple sclerosis, Parkinson’s Disease, chronic Lyme’s disease).
• Neuropathies associated with chronic diabetes mellitus.
• Healthy ageing.
• Inflammatory GIT conditions.
• Gastritis.
• Peptic ulcers.
• Potential adjunct in treatment of Helicobacter pylori (H. pylori).
• Microbiome dysbiosis.
• Immune dysfunction with associated GIT issues.
• Metabolic syndromes (e.g. T2DM, CVD and obesity).
• Adults and older adults.

• When chronic stress is impairing resilience, mental capacity, or mental health.
• To help protect brain health and cognitive function (such as Alzheimer disease, dementia, mild cognitive impairment).
• To help protect against long term neurological damage.
• To help protect against long term neurological damage secondary to diabetes mellitus.
• When improving microbiome diversity, reducing inflammation and supporting immune function.
• For metabolic syndromes (e.g. T2DM, CVD and obesity).
• To support healthy blood sugar balance.

When selecting a lion's mane product, key factors include ingredient form, clinical dosing, purity, excipient profile and manufacturing standards. This product has been specifically developed for practitioner use and compounding, with:



• High-quality, verified raw materials with full traceability.
This is the most premium lion’s mane available in the country, sourced from Aloha Medicinals in the USA.
• Manufacturing in a TGA-licensed GMP facility in Australia.

• Rigorous third-party testing to ensure potency, purity and absence of contaminants.
Give Back Health Clinic Collection Lion's Mane Premium Organic has returned results showing 57% beta glucans, the highest of any lion's mane in the market.
• 100% pure lion's mane powder with no excipients suitable for sensitive patients and custom blends.

This product prioritises efficacy, quality assurance and suitability for tailored prescribing, giving you clinical confidence and patient clarity. Unlike most therapeutic and extemporaneous compounding powders in the marketplace, all our products – including Give Back Health Clinic Collection Lion's Mane Premium Organic– are manufactured and tested in TGA-registered GMP facilities here in Australia, ensuring high standards of quality, safety and efficacy. Every product, every batch, with no exceptions. This means the included ingredients are what they claim to be and the products are therefore more likely to have an actual therapeutic impact. This process also prevents counterfeit and adulterated materials from entering the market. While it adds significantly to our costs, we believe this level of integrity should be the industry standard. Please note that we absorb the extra expense ourselves; it is not passed on to you.

Give Back Health Clinic Collection Lion’s Mane Premium Organic is a full-spectrum extract, containing fruiting body, mycelium, hyphae and primordia. This ensures both hericenones (primarily from the fruiting body) and erinacines (primarily from the mycelium) are retained. These compounds are known for their NGF-stimulating and neurotrophic properties.

This is a standardised, dried, full-spectrum powder using a 10:1 ratio of fresh mushroom to powder (note: not an ethanol or hot water extract, nor a liquid dual extract). This method preserves a broad range of bioactive compounds, including beta-glucans, hericenones, erinacines and polysaccharides – without the selective compound loss that can occur with aggressive solvent extraction.

The powder is dry-processed, DNA-verified, 100% organic, and standardised to:

• ≥25% beta-glucans (actual result: 57%)
• ≥50% total polysaccharides (actual result: 62.5%)
• ≤10% alpha-glucans (actual result: 5.7%)

Finally, Give Back Health Clinic Collection Lion's Mane Premium Organic is the only lion's mane suitable for practitioner prescribing. Not only does it contain the highest theraeputic rating, as demonstrated by testing results, but as an extemporaneous powder it ensures that practitioners are prescribing a product that sits within the regulations. Unfortunately, many of the popular existing lion's mane products fall below our quality standards and outside of the legislation, therefore putting practitioners at risk if prescribing to patients.

The blanket claim that you must use either fruiting bodies or mycelium for all mushroom supplements is fundamentally flawed. This would be equivalent to a herbalist insisting they need only leaves for every herbal medicine they prescribe. The most informed approach is to identify the specific therapeutic actions you're targeting, determine which constituents deliver these effects, and select the part of the ingredient that contains the highest concentration of these active compounds. For our Lion's Mane Premium Organic formula, we've chosen a full-spectrum approach because the key compounds responsible for the cognitive and neurological benefits people seek are present in both the mycelium and fruiting body (Beta glucans - full spectrum; Hericenones – fruiting body; Erinacines - mycelium).

In short, yes. Powders for extemporaneous compounding sit in a unique therapeutic category with its own set of rules. When you choose to use a compounding powder, the expectation is that you will be combining this with other therapeutic nutrients and ingredients to create a personalised medicine. Single ingredient prescribing is, however, possible with extemporaneous compounding ingredients with best practice to ensure that the amount of product in the jar represents the full course for the patient. The quantity of any ingredient you use will be calculated in relation to the prescription length and daily required dose, which is completely specific to an individual patient’s presentation and needs.

• Lion's mane is generally well tolerated.
• Because Give Back Health Clinic Collection Lion’s Mane Premium Organic is a high-potency, therapeutic-grade product, some patients may notice benefits or effects not experienced with lower-potency, non-therapeutic lion’s mane supplements.
• There are no documented major interactions. However, use caution with:
  - Immunomodulators (possible synergistic or additive effects).
  - Monoamine-active medications (e.g. SSRIs), particularly in mood protocols.
  Monitor patients for any changes in symptomatology or sensitivity.
  
• Theoretically, lion's mane may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs. Recommendations is to separate the lion's mane by 2 hours from aspirin and anti-hypotensive and advise patient that if they notice changes in bleeding (small cuts etc), or feel lightheaded on standing (or notice their blood pressure is lower, if testing), to let you know to monitor further.

There is insufficient clinical data to recommend routine use during pregnancy or breastfeeding. Use a risk–benefit approach on a case-by-case basis.

• Add to foods (e.g. yoghurt, soups, smoothies) or to warm (not boiling) liquids such as coffee, tea, cacao or broth. Beta-glucans are heat stable, but prolonged high-heat exposure may degrade some delicate aromatic compounds (e.g. hericenones, erinacines).
• Due to its high purity, this lion’s mane powder does not dissolve easily. We recommend gently swirling the cup while drinking to ensure the powder remains evenly distributed.
• The common range for lion's mane is 1,000 mg – 5,000 mg per day. It is well tolerated at these levels.
• Without knowing your patient’s presentation and requirements, we cannot provide guidelines around appropriate daily dosing and suggest you refer to the literature and common dosage ranges when creating your prescription. Our team of naturopaths are also available for further guidance.

This product contains no excipients. It is 100% pure organic lion's mane powder.

Give Back Health Clinic Collection Lion's Mane Premium is manufactured and tested in TGA-registered GMP facilities here in Australia, ensuring high standards of quality, safety and efficacy. Every product, every batch, with no exceptions. This means the included ingredients are what they claim to be and the products are therefore more likely to have an actual therapeutic impact. This process also prevents counterfeit and adulterated materials from entering the market. While it adds significantly to our costs, we believe this level of integrity should be the industry standard. Please note that we absorb the extra expense ourselves; it not passed on to you.

Give Back Health Clinic Collection Lion's Mane Premium Organic is most commonly used alongside our Nicotinamide Riboside (NR), L-Theanine, Safffron + ZInc, GABA, Curcuma Phospholipids, MagRegulate® and RejuveGen® for additional support, depending on clinical goals.

Absolutely. This can be mixed with any other powder product in the Give Back Health Clinic Collection. For further info on compounding personalised medicines for your patients, see our compounding resources, including a compounding calculator, videos and sample recipes based on real-life cases. Alternatively, reach out if you need assistance or guidance with compounding.

The mushroom is organically cultivated on organic sorghum, not rice. Sorghum allows for a richer, more bioactive nutrient base and avoids the high alpha-glucan/starch load associated with grain-grown mycelium.

Beta glucans are active compounds found in mushrooms that are linked to immune, gut and cognitive support. The extract we use in our Lion's Mane Premium Organic is tested to contain 57% beta glucans, well above industry average.

When determining which part of a mushroom (or herbal medicine for that matter) to use, the most informed approach is to identify the specific therapeutic actions you're targeting, determine which constituents deliver these effects, and select the part of the ingredient that contains the highest concentration of these active compounds. For our Lion's Mane Premium Organic formula, we've chosen a full-spectrum approach because the key compounds responsible for the cognitive and neurological benefits are present in both the mycelium and fruiting body. (Beta glucans - full spectrum; Hericenones – fruiting body; Erinacines - mycelium)

While some products promote fruiting body-only or mycelium-only extracts, we use a full spectum for our Lion's Mane Premium Organic as we want the compounds that are found in numerous parts of the muschroom. This is essential for the most therapeutic activity from the complementary neurotrophic compounds:

• Beta glucans (full spectrum): Neurogenesis, peripheral nerve regeneration and muscle regeneration.
• Hericenones (fruiting body): Stimulate NGF synthesis and NGF gene expression via activation of the protein kinase A signalling pathway.
• Erinacines (mycelium): Cross the blood–brain barrier and induce the expression of NGF in the brain. They demonstrate the ability to stimulate NGF synthesis.

A full-spectrum extract ensures synergy between these pathways and offers broader clinical utility in cognitive, mood and neurodegenerative conditions.

Yes, lion’s mane has preclinical support for:

• Neuroprotection against neuroinflammation and apoptosis.
• Support of myelination and nerve regeneration.
• NGF and BDNF upregulation.
• Reduction of oxidative and inflammatory markers (e.g. TNFα, IL-6).

These mechanisms are relevant in Parkinson’s and other neurodegenerative disorders. Early clinical trials and pilot studies also show benefit in mild cognitive impairment and early Alzheimer’s disease.

A therapeutic range is 1,000–5,000 mg daily. For neurodegenerative conditions, the literature suggests:

• 1–2 scoops daily (each scoop = 1,800 mg)
• Adjust based on individual tolerance and concurrent protocols

Higher end dosing may be appropriate, particularly when paired with BDNF/NGF-enhancing co-factors (e.g. saffron, NR, phospholipids). Use clinical judgement and monitor response.

Yes, lion’s mane is generally well-tolerated with a long history of traditional use. There is no known risk with long-term intake when taken within the recommended dose range.

• Give Back Health Lion’s Mane Premium Organic comes in a smaller 80g tub, whereas our discontinued lion’s mane powder was in a 100g tub.
• This change reflects the superior quality of our new product - it is authenticated, organic, 100% pure medicine grade, and the most premium lion’s mane available in Australia.
• With an industry-first 57% beta-glucan content, it is far more concentrated and potent, meaning you need less to achieve the same (or even better) results.