MagSleep combines a highly bioavailable form of magnesium with the clinically effective dosages of L-glycine, L-theanine and Herbatonin®. It works synergistically to calm the central nervous system, quiet the mind, promote optimal sleep architecture and support circadian rhythms to promote restorative, high-quality sleep. It is a listed medicine (AUST L 524890) on the Australian Register of Therapeutic Goods (ARTG) and comes in powder form.

• Promotes sleep onset, duration, and healthy sleep architecture.
• Improves sleep impacted by insomnia, stress, anxiety or a racing mind.
• Contains Sleepatonin®/Herbatonin®, a bioidentical, non-synthetic plant-based melatonin.
• Supports sleep quality in patients with comorbid mental health presentations or chronic illness.

• L-glycine acts at NMDA receptors in the suprachiasmatic nucleus to support sleep onset.1,9
• Promotes a peripheral drop in core body temperature consistent with sleep initiation.1
• Magnesium supports GABAergic tone and physiological neuromuscular relaxation.3,21
• Contributes to longer total sleep time and reduced sleep onset latency.3,8,21
• L-theanine increases alpha-brainwave activity, supporting a calmer transition to sleep.2,11,22
• Dampens sympathetic nervous system arousal without causing sedation.10
• Reduces perceived stress and HPA-axis reactivity for racing-mind presentations.10,11
• Plant-source melatonin acts on MT1/MT2 receptors to support circadian phase alignment.5,23

See factsheet for specific scientific findings and a full list of references.

Magnesium

• Improves GABAergic tone, promotes neuromuscular relaxation, and modulates the HPA-axis to soften the stress response
• Reduces sleep onset latency by 17.36 min versus placebo.3
• Increases total sleep time in patients with insomnia.3,20
• Increases deep sleep.21
• Reduces serum cortisol and stress parameters.13,20
• Improves sleep onset, duration and waking feeling refreshed in depressed patients.19

L-glycine

• Activates the NMDA receptor in the suprachiasmatic nucleus and helps to drop core body temperature
• Improves sleep onset latency and time in deep sleep.1,6,9
• Improves sleep quality and decreases fatigue.9
• Increases sleep efficacy and improves daytime alertness and focus.9
• Reduces CNS excitation to promote sleep onset, duration and quality.1,6,9,24-26
• Reduces CNS excitation and improves multiple mental health parameters.9,24-26

L-theanine

• Increases alpha-brainwave activity and dampens sympathetic tone to quiet a racing mind
• Improves sleep onset latency.2,7
• Reduces sleep disturbance and reliance on sleep medication.2,11
• Improves overall subjective sleep quality, and reduces CNS excitation.2,22
• Reduces CNS excitation and helps calm the mind to relax into sleep.4,10
• Reduces CNS excitation and improves multiple mental health parameters.15,16

Melatonin (Herbatonin®/Sleepatonin®)

• Binds MT1/Mt2 receptors and realigns the circadian rhythm for consistent sleep onset and patterning.
• Improves sleep onset latency.27-29
• Improves sleep initiation, total sleep time and overall sleep quality.5,27-30
• Preserves physiological sleep structure and architecture without suppressing slow wave sleep.23
• Improves sleep onset and duration across multiple chronic illness presentations.31-33

Together, these ingredients work synergistically to restore night-long sleep architecture.

• People with difficulty falling asleep, staying asleep or waking refreshed.
• People with insomnia or non-restorative sleep.
• People who are stressed, anxious or have a racing mind with subsequent impact to sleep.
• People who wake anxious or with elevated cortisol.
• People with comorbid mental health presentations seeking sleep support.
• People with chronic illness wanting to improve sleep and quality of life.

• To decrease the time it takes to fall asleep.1-3
• To support sleep maintenance, duration and architecture.3,4
• To support refreshing sleep, healthy circadian rhythms and sleep patterns.5-9
• To support sleep during periods of acute or chronic stress.10-12
• To calm a racing mind prior to sleep.4,6,10
• To support sleep in patients with elevated cortisol or HPA dysregulation.11,13,14
• To support sleep quality in patients with comorbid mental health presentations.4,15-19
• To support sleep quality in patients with chronic illness.9,13,17,20

When selecting a product, key factors include interactions, ingredient form, clinical dosing, purity, clinical research, excipient profile and manufacturing standards. This practitioner-only formulation stands apart through its clinical integrity and evidence-aligned design. Key points of difference include:

• Featuring clinically effective doses of magnesium, L-glycine, L-theanine and Sleepatonin®/Herbatonin®.
• Therapeutic dosing based on the latest research using bioavailable ingredients to maximise absorption and enhance clinical outcomes. Each scoop of MagSleep contains the clinically trialled dosage of magnesium citrate (350 mg), L-glycine (3 g), L-theanine (200 mg), and Sleepatonin®/Herbatonin® (50 mg).
• Contains an all-natural and plant-based alternative unlike others that are either synthetic (most common and derived from petrochemicals) or extracted from the pineal glands of animals. It is bio-identical, as demonstrated in all third party testing.
• High-quality, verified raw materials with full traceability.

• Provides clinical benefits across multiple sleep-specific pathways
  - GABAergic modulation
  - NMDA receptor-mediated sleep onset
  - Sympathetic nervous system dampening
  - Circadian phase alignment
• Clean formula free from flavours, sweeteners or commonly used excipients.
• Manufactured in a TGA-licensed GMP facility to ensure consistent quality.
• Comprehensive third-party testing for potency, purity and contaminants.


This product is designed to offer clinicians peace of mind and patients’ better outcomes, supporting targeted use in a range of clinical applications.

• Levodopa/carbidopa: Magnesium can reduce the bioavailability of levodopa/carbidopa. These ingredients should not be taken together.
• Antihypertensive drugs: L-theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
• Do not give to patients taking prescribed pharmaceutical sleep medications.
• May cause daytime sleepiness/grogginess. Do not operate machinery or drive within 4 to 5 hours after supplementation.

At Give Back Health, we follow a conservative risk/benefit approach and recommend healthcare practitioners assess use on a case-by-case basis, depending on individual patient needs, context and response to treatment.

• Magnesium: Likely safe in pregnancy and lactation when used appropriately. The Natural Medicines Database rates oral magnesium intake up to 350 mg/day as safe within this population. MagRelax® delivers 350 mg per 5.3 g scoop.
• L-Glycine: While Glycine is not specifically contraindicated in pregnancy and lactation, there is insufficient reliable evidence so we recommend a risk/benefit approach to use.
• L-Theanine: While L-Theanine is not specifically contraindicated in pregnancy and lactation, there is insufficient reliable evidence so we recommend avoid use. Use a risk/benefit approach during pregnancy and lactation due to insufficient safety data.
• Sleepatonin®/Herbatonin®: Due to insufficient reliable data, we recommend avoid use. Use a risk/benefit approach during pregnancy and lactation due to insufficient safety data.
  [Melatonin use during pregnancy and lactation: A scoping review of human studies]

• Mix 1 level scoop (5.6 g) into 50 mL of water and consume immediately, or as recommended by your healthcare practitioner. Take 30 minutes before bed to enhance sleep.
• The common dosage range for magnesium is 350 – 700 mg/day
• The common dosage range for L-Glycine is 3 – 9 g/day
• The common dosage range for L-Theanine is 100 – 400 mg/day
• Sleepatonin®/Herbatonin® contains 1% melatonin. The physiological dosage range for Sleepatonin®/Herbatonin® is 30 – 80 mg/day (equivalent to 0.3 mg – 0.8 mg melatonin). The jet lag or shift work dose is 100 mg – 300 mg (equivalent to 1 mg – 3 mg melatonin.

Most ingredients have a quick onset. Individuals should experience a calming effect within 30 minutes (for nervous system excitation and sleep benefits). For other benefits, results are generally seen within 2-4 weeks, with further improvement by 8-12 weeks.

Give Back Health Clinic Collection MagSleep is a clean formula free from many commonly used flavours, sweeteners or commonly used excipients, making it a suitable option for many. It is a low excipient formulation with minimal low-to-no allergen excipients (e.g. glycine for manufacturing purposes). See the Free Froms & Allergy Info details in the main product description above.

Excipients include: Chlorella vulgaris, glycine and Oryza sativa

Give Back Health Clinic Collection MagSleep is manufactured and tested in TGA-registered GMP facilities here in Australia, ensuring high standards of quality, safety and efficacy. Every product, every batch, with no exceptions. This means the included ingredients are what they claim to be and the products are therefore more likely to have an actual therapeutic impact. This process also prevents counterfeit and adulterated materials from entering the market. While it adds significantly to our costs, we believe this level of integrity should be the industry standard. Please note that we absorb the extra expense ourselves; it is not passed on to you.

We use:

• Bioavailable and highly absorbable ingredient forms of magnesium (as magnesium citrate) and L-glycine to maximise absorption and clinical outcomes.
• Sleepatonin®/Herbatonin®, a proprietary blend made from rice, alfalfa and chlorella exclusively distributed by NHI Inc (Symphony Natural Health, USA).
• A bio-fermented 100% pure medicine-grade L-theanine. It is vegan and not derived from green tea.

Conventional melatonin is created from either the pineal glands of animals or more commonly petrochemicals. Sleepatonin®/Herbatonin® is bioidentical to melatonin and is an all-natural alternative, containing rice, alfalfa and chlorella. Our Sleepatonin®/Herbatonin® material is standardised to 1% melatonin, which we independently validate at NICM in Australia.
As each dose of MagSleep contains 50 mg of Sleepatonin®/Herbatonin®, this means each dose contain 0.5 mg of melatonin (the physiological dose).

Give Back Health Clinic Collection MagSleep is most commonly used alongside our Mood-D®, Ashwagandha Clarity, Multi VMN, GABA, Curcuma Phospholipids and RejuveGen® for additional support, depending on clinical goals.

Yes. MagSleep is often used in combination with complementary nutrients and products, such as:

• GABA
• Zinc Picolinate
• Mood-D®
• Saffron + Zinc
• Meno-P

When building a protocol, consider total magnesium intake and avoid overlapping ingredients if already present in other formulas.

Yes of course! MagSleep was developed as many practitioners were already regularly compounding a version of it. Whilst the dosages offered in MagSleep are the most frequently used and considered effective for most, you can add any of the following ingredients to adjust the levels of any ingredient:

• Sleepatonin®
• MagRelax®
• L-glycine
• L-theanine

When building a protocol, consider the following dosage ranges:

• The common dosage range for magnesium is 350 – 700 mg/day
• The common dosage range for L-glycine is 3 – 9 g/day
• The common dosage range for L-theanine is 100 – 400 mg/day
• Sleepatonin®/Herbatonin® contains 1% melatonin. The physiological dosage range for Sleepatonin®/Herbatonin® is 30 – 80 mg/day (equivalent to 0.3 mg – 0.8 mg melatonin). The jet lag or shift work dose is 100 mg – 300 mg (equivalent to 1 mg – 3 mg melatonin.

Absolutely. This can be mixed with any other extemporaneous compounding powder product in the Give Back Health Clinic Collection. For further info on compounding personalised medicines for your patients, see our compounding resources, including a compounding calculator, videos and sample recipes based on real-life cases. Alternatively, reach out if you need assistance or guidance with compounding.

Magnesium citrate is a highly bioavailable and well-researched form. Glycine is included in MagSleep at a clinically validated therapeutic dose. To get the same glycine dose using magnesium glycinate, you'd need a significantly higher magnesium intake, which would likely cause gastrointestinal side effects like diarrhoea. MagSleep allows you to get the full benefits of both ingredients without overloading the system, or underdosing the glycine.

Yes. MagSleep contains only magnesium citrate, glycine, theanine and Sleepatonin®/Herbatonin® with no flavours, fillers or sweeteners, which makes it generally well tolerated. As with all magnesiums, some patients may experience mild softening of stools at full-dose levels due to the inclusion of magnesium citrate, so it may be useful to start with a lower dose and build gradually. You can adjust the levels of theanine, glycine and Sleepatonin®/Herbatonin® with our compound ingredients if you need to slowly titrate the dose.

Give Back Health Clinic Collection MagSleep has a very slight herby profile, with a mild sweetness contributed by the L-glycine which is naturally sweet. There are no sweeteners or flavours added.

Sleepatonin®/Herbatonin® contains alfalfa (Medicago sativa), a herb naturally rich in polyphenols, flavonoids and tannins. These compounds are known to darken when exposed to oxygen, heat, or moisture, and in some circumstances can form dark localised clumps during storage.

Yes, but with a small caveat. While the magnesium component remains stable in warm drinks, glycine and theanine can degrade when exposed to high heat and there's no stability data available for Sleepatonin®/Herbatonin® when exposed to higher temperatures. If you're adding MagSleep to a warm beverage, avoid boiling water and drink it soon after mixing for best effect. Our recommendation is add to a room temperature or cold beverage and consume immediately.

Give Back Health Clinic Collection MagSleep is suitable 30 minutes before bed to aid sleep architecture and may cause drowsiness if taken during the day.
If you’re looking for a magnesium suitable for daytime use, you might like to consider MagRelax® or MagRegulate®.

To make this choice easy, we’ve supplied a handout to easily assess the differences to consider when deciding between MagRelax®, MagRegulate® and MagSleep for your patient.

• Use MagRelax® to relax and nurture the central nervous system (CNS) when under excitation or oxidative load (e.g. alcoholism, drug use, serious mental health presentations). Use day or night.
• Use MagRegulate® to regulate a range of processes and systems once the CNS is relaxed and more receptive to taurine. Use day or night.
• Use MagSleep to support restorative sleep architecture, particularly in patients with stress, anxiety or mental health presentations impacting sleep onset, maintenance and/or quality. Use at night.

Mag Comparison Chart

Due to the L-theanine component, the dosing recommendation is specific to the adult population. Dosage and need should be carefully assessed.

Despite this, a 2011 randomised, double-blind, placebo-controlled clinical trial involving 98 boys with ADHD between 8-12 years demonstrated no adverse events after taking 400 mg of L-theanine for 6 weeks.

Magnesium, glycine and melatonin have all been shown to be safe in paediatric populations. However, dosage depends on the age and weight of the child and how sensitive they are to supplementation. We generally recommend practitioners start by addressing the foundations of sleep hygiene, diet, exercise, blue light exposure, etc. prior to starting at lower doses of MagSleep.

• Magnesium and glycine are reportedly safe for long term use.
• Long term supplementation of L-theanine presents no adverse events after 4, 8 and 12 weeks of supplementation.
• Physiological doses of melatonin (between 0.3-0.9 mg) as present in one dose of MagSleep (0.5 mg melatonin), has been shown to be suitable for long term use and enhances changes of feeling refreshed upon waking.