Give Back Health Clinic Collection Saffron + Zinc contains ingredients shown to help reduce the occurrence of mild anxiety, improve low mood and decrease symptoms of stress. Saffron + Zinc provides DNA certified, 100% vertically integrated and clinically trialled saffron. Taking two capsules daily provides the therapeutic dosage to encourage mental wellbeing and healthy mood. It is a listed medicine (AUST L 445615) on the Australian Register of Therapeutic Goods (ARTG).

• Saffron (affron®) improves mood, reduces stress and anxiety and nurtures the nervous system.
• Proven to significantly reduce depressive symptoms in
  both adolescents and adults.
• Clinical trials have demonstrated saffron (affron®) is as effective as commonly prescribed SSRIs.
• Supports mental health stability, including reducing and relieving symptoms of stress and anxiety.
• Helps reduce the occurrence and severity of poor mood status (stress, anxiety and depression).
• Improves sleep quality.
• Reduces PMS symptoms.
• DNA certified, 100% vertically integrated and clinically trialled saffron.
• Taking two capsules daily delivers the clinically trialled dosage to support healthy mood balance, emotional wellbeing and relieve symptoms of stress.
• Promotes mental wellbeing during times of increased demand.
• Supports healthy cognitive, mental and nervous system function.
• Targeted, fast acting, clinic-grade mood support.
• Includes affron® saffron, clinically proven as an effective option for mood support.

Nurtures the nervous system and balances mood

• Provides antioxidant effects.
• Provides anti-inflammatory effects.
• Provides serotoninergic effects.
• Provides HPA modulating effects.
• Provides neuroprotective effects.
• Saffron downregulates HPA activity; a mechanism likely to reduce the effects of stress.
• Extensive research into saffron's constituents, especially safranal, crocin, crocetin, and picrocrocin, consistently demonstrate a range of synergistic biological activities supportive of mental health. These actions include anti-depressant, anti-inflammatory, anti-nociceptive, and sedative actions. Memory-enhancing and neuroprotective effects were also observed.
• Saffron inhibits the re-uptake of several neurotransmitters including serotonin, norepinephrine and dopamine in animal models of depression.
• Saffron reduces symptoms of premenstrual syndrome including anxiety, depression, sleep disturbance and pain.
  

Antioxidant, anti-inflammatory

• Saffron constituents safranal and crocetin bind to acetyl-cholinesterase inhibiting it’s activity; pharmaceuticals used in the treatment of Alzheimer’s disease act via a similar mechanism.
• Zinc is critical to brain-derived neurotropic factor (BDNF), which promotes neurogenesis and neuroplasticity; vital to maintaining cognitive funciton.
• Saffron constituents include crocin, crocetin, zeaxanthin, lycopene and α and β carotenes which have antioxidant, anti-apoptotic and anti-inflammatory actions.

Vital role in the nervous system function

• The relationship between zinc and depression may be linked to its action on brain-derived neurotropic factor (BDNF), which promotes neurogenesis and differentiation.
• Zinc modulates NMDA receptor activation sensitivity.

See factsheet for specific scientific findings and a full list of references.

Nurtures the nervous system and balances mood

• Significantly reduces depressive symptoms in adolescents and adults.
• 72% of participants taking Affron® experienced a clinically meaningful improvement in low mood symptoms after 12 weeks.
• Significantly improves mood and reduces stress and anxiety.
• Suitable for use alongside antidepressants.
• Shown to be as effective as antidepressants.
• Significantly improves sleep quality and mood upon waking.
• Improves psychological symptoms in women experiencing perimenopause.
• Provides antioxidant effects.
• Provides anti-inflammatory effects.
• Provides serotoninergic effects.
• Provides hypothalamus-pituitary adrenal (HPA) modulating effects.
• Provides neuroprotective effects.
• Double-blind, randomised placebo-controlled trials of healthy adults, including young adults, experiencing low mood report significant benefits, compared to placebo in mood, and resilience to stress.
• Saffron was found to significantly reduce symptoms of mild to moderate depression compared to placebo in a systematic review of double-blind, placebo-controlled clinical trials and
  non-inferior to two SSRIs.
• Saffron found to significantly reduce PMS symptoms, particularly of depression in well- designed double blind, placebo controlled clinical trials.
  

Antioxidant, anti-inflammatory

• Both zinc and saffron are potent antioxidants. Oxidative stress is implicated in the pathogenesis of neurodegenerative conditions.
• Saffron and crocin have been shown to prevent oxidative stress in the hippocampus and protect against learning and memory deficits.
• A systematic review of small clinical trials found saffron to be a promising option in mild cognitive decline and Alzheimer's disease.
• Saffron was as effective as common pharmaceuticals on cognition and functional status and superior to placebo in patients with Alzheimer’s disease.
• A systematic review of the effect of saffron on subclinical inflammation found a significant reduction in serum CRP & TNF- in those with relatively high baseline levels.

Vital role in the nervous system function

• Zinc is integral to nervous system development, maintenance and normal function.
• Zinc is associated with emotional balance. It is maintained at high levels within glutamatergic neurons in the limbic system, acting as an inhibitory modulator.
• Zinc absorption is impacted by ageing, impaired gastrointestinal function and by commonly used medications (oral hypoglycaemics, antacids, anti-inflammatories and others).
• A meta-analysis confirmed that serum zinc levels are lower in people with symptoms of depression compared to healthy controls.

• People in emotional and mental vulnerability.
• People experiencing low mood or adjunct to treatment for depression.
• People experiencing poor quality sleep.
• Women who experience PMS.
• People seeking to optimise their health/healthy ageing.
• People with chronic health conditions, both mental and physical associated with oxidative stress and inflammation.
• People with concentration and memory issues.
• People with low zinc in their diet, such as older adults, vegetarians and vegans.
• People with high alcohol intake.
• People with underlying gastro-intestinal (GIT) disorders.
• Adolescents and adults.

• When feeling emotionally or mentally vulnerable.
• When experiencing low mood or anxiety.
• When stress is affecting mood balance.
• Prevention of cognitive deterioration secondary to stress.
• When sleep quality is compromised by low mood, anxiety or stress.
• To support wellness and healthy ageing.
• Prevention of mild cognitive decline especially when associated with stress.
• In chronic conditions mediated by oxidative stress causing inflammation.
• During depression and/or anxiety; these conditions are strong predictors of chronic illness.
• In emotional or mental imbalance and low mood.
• To prevent marginal zinc deficiency which is common in older adults and those eating a plant-based diet.

When selecting a mood support product, key factors include interactions, ingredient form, clinical dosing, purity, clinical research, excipient profile and manufacturing standards. This practitioner-only formulation stands apart through its clinical integrity and evidence-aligned design. Key points of difference include:

• Saffron + Zinc is a simple formula that's highly effective to support mood, stress/anxiety, emotional imbalances and the downstream effects on sleep, nervous system and general wellness.
• Therapeutic dosing based on the latest research.
 Saffron + Zinc contains the clinically trialled daily dosage of affron® saffron (28 mg) and zinc (as zinc citrate) (10 mg).
• Bioavailable and researched ingredient forms to maximise absorption and clinical outcomes.
We used affron® saffron as it's the most studied, standardised saffron extract.
• Manufactured in a TGA-licensed GMP facility to ensure consistent quality.

• Comprehensive third-party testing for potency, purity and contaminants.

• Minimal excipients, no unnecessary fillers or additives. Saffron + Zinc is clean formula with only the necessary excipients added as a requirement of the manufacturing process. Even our capsules are the cleanest avialble, made from water and hypromellose derived from sustainably sourced pine trees.
• This product is designed to offer clinicians peace of mind and patients better outcomes, supporting targeted use in a range of clinical applications.

When selecting a mood support product, key factors include interactions, ingredient form, clinical dosing, purity, clinical research, excipient profile and manufacturing standards. This practitioner-only formulation stands apart through its clinical integrity and evidence-aligned design. Key points of difference include:

• Saffron + Zinc is a simple formula that's highly effective to support mood, stress/anxiety, emotional imbalances and the downstream effects on sleep, nervous system and general wellness.
• Therapeutic dosing based on the latest research.
 Saffron + Zinc contains the clinically trialled daily dosage of affron® saffron (28 mg) and zinc (as zinc citrate) (10 mg).
• Bioavailable and researched ingredient forms to maximise absorption and clinical outcomes.
We used affron® saffron as it's the most studied, standardised saffron extract.
• Manufactured in a TGA-licensed GMP facility to ensure consistent quality.

• Comprehensive third-party testing for potency, purity and contaminants.

• Minimal excipients, no unnecessary fillers or additives. Saffron + Zinc is clean formula with only the necessary excipients added as a requirement of the manufacturing process. Even our capsules are the cleanest avialble, made from water and hypromellose derived from sustainably sourced pine trees.
• This product is designed to offer clinicians peace of mind and patients better outcomes, supporting targeted use in a range of clinical applications.

No major interactions.

At Give Back Health, we follow a conservative risk/benefit approach and recommend healthcare practitioners assess use on a case-by-case basis, depending on individual patient needs, context and response to treatment.

• Saffron: when used orally in amounts exceeding those commonly found in foods, larger amounts of saffron have uterine stimulant and abortifacient effects. Recommend avoid use.
• Zinc: Suitable for use during pregnancy and lactation.

Take 2 capsules per day. Can be taken before bed to support better sleep.

• The clinically trialled daily dosage for affron® saffron is 28 mg.
• Recommended daily dose of zinc is 10 mg - 25 mg.

Give Back Health Clinic Collection Saffron + Zinc provides the clinically trialled dosage of affron® and a therapeutic dosage of zinc.

Results are generally seen within 2-4 weeks, with further improvement by 4-8 weeks.

Give Back Health Clinic Collection Saffron + Zinc is a simple, clean formula free from many commonly used excipients, making it a suitable option for many. It is an ultra-low excipient formulation with minimal low-to-no allergen excipients. See the Free Froms & Allergy Info details in the main product description above.

• Give Back Health Clinic Collection Saffron + Zinc is manufactured and tested in TGA-registered GMP facilities here in Australia, ensuring high standards of quality, safety and efficacy. Every product, every batch, with no exceptions.
• We use affron® saffron, DNA certified, 100% vertically integrated and clinically trialled saffron sourced from Spain.
• We use gold-standard Capsugel® Vcaps® capsules from Lonza, widely considered the cleanest on the market. Unlike many capsules that contain gelatine or unnecessary additives like sodium lauryl sulphate, ours are made from just two ingredients: plant-based hydroxypropylmethylcellulose (HPMC) (AKA hypromellose), derived from sustainably sourced pine trees, and water. That’s it. These capsules are vegan, non-GMO Project Verified, Kosher and Halal certified, and Vegetarian Society approved.

Give Back Health Clinic Collection Saffron + Zinc is most commonly used alongside our Nicotinamide Riboside (NR), Natural Energy, NAC, L-Theanine, GABA, L-Glycine, MagRelax® and MagRegulate® for additional support, depending on clinical goals.