Give Back Health Clinic Collection L-Glycine is a practitioner-only nutritional supplement that provides 100% pure medicine-grade L-glycine. L-Glycine is a conditionally essential amino acid which acts rapidly in the central nervous system to inhibit excitation. As there is no regulation over its uptake (unlike taurine) this is the perfect option to lead with, particularly when the brain is under excitatory overload (e.g. conditions such as depression, acute stress, drug use and extreme insomnia).

• Reduces CNS excitatory excess.
• Effective central nervous system (CNS) anti-inflammatory.
• Promotes sleep onset and healthy sleep architecture.
• Conditionally essential amino acid. Involved in the regulation of 1-carbon metabolism.
• Acts rapidly (within 30 mins) to inhibit nervous system excitation.
• Suitable for use both during the day and prior to sleep.

• L-Glycine is an inhibitory neurotransmitter. It rapidly crosses the blood-brain barrier and modulates NMDA receptor activity, helping to reduce CNS excitation and inflammation.
• Due to its role in one carbon metabolism and bile synthesis, glycine has many possible therapeutic applications.
• 50% of the inhibitory receptors in the CNS are glycine receptors.
• Glycine is a building block for the major antioxidant glutathione (GSH), which is also a substrate for various antioxidant enzymes.
• Anti-inflammatory and antioxidant activity via action on the glycine receptor.
• Glycine conjugates a range of endogenous and exogenous xenobiotic metabolites increasing their solubility.
• Glycine acts as an inhibitory neurotransmitter in the central nervous system via the glycine receptors (GlyRs).
• Modulates N-methyl-D-aspartate (NMDA) receptor excitation.
• Glycine is an essential component of collagen, making up one third of the amino acid units.
• Glycine is the substrate for the enzyme glycine-N-methyltransferase (GNMT) and catalyses the regeneration of methionine from homocysteine.
• GNMT is also key to ratio of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) and so to methyl transfer in numerous biological process and in genetic stability.
• Glycine is a main component of bile acids, so has a key role in emulsification, digestion and absorption of lipids and lipid soluble vitamins.
• Serum glycine levels are proposed as markers of insulin resistance and may predict intramuscular and abdominal adiposity in older adults.

• People with conditions associated with CNS inflammation and excitation (such as depression, chronic insomnia, acute stress and drug use).
• People with occupational exposure to environmental toxins.
• Those experiencing sleep difficulties including prolonged sleep latency, poor quality sleep, insomnia and not refreshed by sleep.
• Individuals with low dietary protein intake.
• People recovering from surgery, burns, convalescence.
• People with bile insufficiency and poor fat absorption and digestion.
• Consider for people in elevated homocysteine levels.
• Consider for people in hypo-methylators.
• Suitable for children, teens, adults and older adults.

• Due to its role in one carbon metabolism and bile synthesis, glycine has many possible therapeutic applications. L-Glycine may be considered in presentations involving CNS excitability, poor sleep onset, stress, drug or alcohol withdrawal, oxidative stress, methylation support and bile insufficiency.
• As there is no regulation over its uptake (unlike taurine) this is the perfect option to lead with, particularly when the brain is under excitatory overload (e.g. conditions such as depression, acute stress, drug use and extreme insomnia).
• To help calm the CNS when exposed to chronic excitation.
• As a neuromodulator in treatment programs for chronic alcohol or drug use.
• Chronic conditions associated with oxidative stress.
• Chronic conditions associated with CNS inflammation.
• To help with sleep difficulties.
• To improve sleep quality.
• To facilitate falling to sleep.
• To reduce insomnia particularly when caused by stress.
• Low protein intake relative to demand (children & adults).
• To support healthy ageing.
• During healing and convalescence.
• In high oxidative stress environments.
• When homocysteine levels are high.
• When low methylation is suspected.
• When indigestion is associated with poor fat digestion and low bile production.
• NAFLD.

When selecting an L-Glycine product, key factors include clinical research on the raw material, clinical dosing, purity, excipient profile and manufacturing standards. Unlike herbal ingredients, which are complex and vary significantly across the many different grades available, single nutrients are far simpler to assess. Source and quality are still essential, but they are much easier to control and verify. If a material is authenticated and genuinely pure, the body can be expected to respond the same way regardless of supplier or brand name. Where this cannot be confirmed, the supplier and manufacturing process become critical.
The key questions to ask are: Is it pure? Has every batch been independently tested to confirm this? Is it free from impurities? Is it the correct isomer, where relevant? Is it stable over time and in combination with other ingredients?

Our L-Glycine meets every one of these criteria. It is authenticated, independently tested on every batch, free from impurities, the correct isomer where relevant, and stable, so you can be confident you are receiving the full clinical dose stated on the label.

This product has been specifically developed for practitioner use and compounding, with:


• High-quality, verified raw materials with full traceability.

• Manufacturing in a TGA-licensed GMP facility in Australia.

• Rigorous third-party testing to ensure potency, purity and absence of contaminants.

• 100% pure L-glycine powder with no excipients suitable for sensitive patients and custom blends.

This product prioritises efficacy, quality assurance and suitability for tailored prescribing, giving you clinical confidence and patient clarity. Unlike most therapeutic and extemporaneous compounding powders in the marketplace, all our products – including Give Back Health Clinic Collection L-Glycine – are manufactured and tested in TGA-registered GMP facilities here in Australia, ensuring high standards of quality, safety and efficacy. Every product, every batch, with no exceptions. This means the included ingredients are what they claim to be and the products are therefore more likely to have an actual therapeutic impact. This process also prevents counterfeit and adulterated materials from entering the market. While it adds significantly to our costs, we believe this level of integrity should be the industry standard. Please note that we absorb the extra expense ourselves; it is not passed on to you.

In short, yes. Powders for extemporaneous compounding sit in a unique therapeutic category with its own set of rules. When you choose to use a compounding powder, the expectation is that you will be combining this with other therapeutic nutrients and ingredients to create a personalised medicine. Single ingredient prescribing is, however, possible with extemporaneous compounding ingredients with best practice to ensure that the amount of product in the jar represents the full course for the patient. The quantity of any ingredient you use will be calculated in relation to the prescription length and daily required dose, which is completely specific to an individual patient’s presentation and needs.

• L-Glycine is generally Well tolerated. Even at 9 g/day it did not induce daytime sleepiness.
• There is a theoretical interaction with Clozapine (Clozaril), where glycine may decrease the effectiveness of clozapine and therefor worsen symptoms of schizophrenia. Caution is advised. No significant interactions with SSRIs have been reported but monitor high doses clinically.

While L-Glycine is not specifically contraindicated in pregnancy and lactation, there is insufficient reliable evidence so we recommend avoid use.

• We typically recommend mixing with water.
• The common range for glycine is 3,000 mg – 9,000 mg per day. It is well tolerated at these levels.
• Without knowing your patient’s presentation and requirements, we cannot provide guidelines around appropriate daily dosing and suggest you refer to the literature and common dosage ranges when creating your prescription. Our team of naturopaths are also available for further guidance.

Glycine has a very quick onset. Individuals should experience a calming effect within 30 minutes (for nervous system excitation and sleep benefits). For metabolic function and inflammatory benefits, results are generally seen within 2-4 weeks, with further improvement by 8-12 weeks.

This product contains no excipients. It is 100% pure L-glycine powder.

Give Back Health Clinic Collection L-Glycine is manufactured and tested in TGA-registered GMP facilities here in Australia, ensuring high standards of quality, safety and efficacy. Every product, every batch, with no exceptions. This means the included ingredient is what they claim to be and the products are therefore more likely to have an actual therapeutic impact. This process also prevents counterfeit and adulterated materials from entering the market. While it adds significantly to our costs, we believe this level of integrity should be the industry standard. Please note that we absorb the extra expense ourselves; it is not passed on to you.

Give Back Health Clinic Collection L-Glycine is most commonly used alongside our NAC, L-Theanine, Nicotinamide Riboside (NR), Saffron + Zinc, Zinc Picolinate and RejuveGen® for additional support, depending on clinical goals.

Absolutely. This can be mixed with any other powder product in the Give Back Health Clinic Collection. For further info on compounding personalised medicines for your patients, see our compounding resources, including a compounding calculator, videos and sample recipes based on real-life cases. Alternatively, reach out if you need assistance or guidance with compounding.

No. Glycine uptake is not receptor-limited and there is no known ceiling for absorption. It is generally well tolerated up to 10-15 g/day, although higher doses may cause some GI discomfort.

Yes, glycine is often used in children when low protein intake, sleep issues or CNS excitability are present. A starting dose of around 1.5 grams is often recommended, but dosage should be assessed case-by-case.

Yes. Glycine levels are known to decrease with age and may be beneficial during convalescence, recovery and in frail older adults.